Donna’s senior prom is supposed to be the best night of her life, though a sadistic killer from her past has different plans for her and her friends.

Flight 7500 departs Los Angeles International Airport bound for Tokyo. As the overnight flight makes its way over the Pacific Ocean during its ten-hour course, the passengers encounter what appears to be a supernatural force in the cabin.

A television reporter and her cameraman are trapped inside a building quarantined by the CDC after the outbreak of a mysterious virus which turns humans into bloodthirsty killers.