In 1959, an alien experiment crashes to earth and infects a fraternity member. They freeze the body, but in the modern day, two geeks pledging a fraternity accidentally thaw the corpse, which proceeds to infect the campus with parasites that transform their hosts into killer zombies.

On the fifteenth anniversary of the exorcism that claimed Father Damien Karras’ life, Police Lieutenant Kinderman’s world is once again shattered when a boy is found decapitated and savagely crucified.